Ageing Seminars 2026 - Dr. Delphine Larrieu

On June 19th, at 11.00am, Lisbon time, we welcome Doctor Delphine Larrieu, who will be presenting “New resistance and resilience pathways in ageing: the role of nuclear envelope integrity”. The seminar will be held at Auditorium 2, Faculty of Medicine Building, Campus I – Central Building, University of Coimbra and online. For online attendance, registration is mandatory through this here. Registered participants will receive a link one day before the seminar.

Bio: Dr. Delphine Larrieu is currently a Principal Investigator at Altos Labs in Cambridge where she contributes to the mission of restoring cell health and resilience in ageing. After completing her PhD at the University Grenoble Alpes in France, Dr Delphine Larrieu moved to the University of Cambridge in 2011 for her postdoctoral research in Steve Jackson Laboratory. She obtained personal funding from EMBO and from the Medical Research Council (MRC) that allowed her to develop an independent line of research, focusing on understanding nuclear envelope function and its links with disease, more specifically premature ageing. In 2017, Delphine was awarded a Wellcome Trust Sir Henry Dale fellowship, to launch her own lab at the Cambridge Institute for Medical Research to pursue her research in the field of nuclear envelope. During this period, she developed pioneering approaches based on the principle of synthetic rescue and relying on cutting-edge whole genome genetic screening approaches. Her work identified novel, unexpected targets and cellular pathways that can reverse several age-related nuclear envelope phenotypes in cells from progeria patients. Driven by her discoveries, Delphine co-founded Adrestia Therapeutics, a synthetic rescue company dedicated to restoring cellular balance in genetic diseases. The company's vision, directly inspired by her research, recently culminated in its acquisition by Insmed. In 2022, she was appointed Assistant Professor at the Department of Pharmacology, University of Cambridge. Here, her efforts concentrated on characterising and expanding the number of targets that could be exploited therapeutically to extend health and lifespan in progeria syndromes as well as in ageing. Her journey continues at Altos Labs Cambridge, which she joined in 2024, bringing her expertise to the forefront of cellular rejuvenation.

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